HOUSTON—A tough night for the Colts in Houston as Indianapolis comes out on the losing end of a 20-17 score.
The Colts took a 20-17 lead into the final quarter, but Deshaun Watson hit DeAndre Hopkins with a 30-yard touchdown pass early in the fourth to put Houston ahead 20-17. It was Hopkins' second touchdown catch of the game.
The Texans defense then kept the Colts at bay for the remainder of the game.
Houston, at 7-4, takes over first place in the AFC South, while the Colts fall to 6-5 and second place in the division.
In the battle of quarterbacks, Watson was the clear winner, passing for 298-yards to just 129 by Jacoby Brissett. Watson's pair of touchdown passes to Hopkins were from 35 and 30-yards.
Indianapolis receiver T.Y. Hilton returned following an injury, but had some critical dropped passes and totaled just 18-yards.
A bright spot for the Colts was running back Jonathan Williams who rushed for over 100-yards for the second straight game and scored one touchdown.
Indianapolis next takes on Tennessee, Dec. 1 at Lucas Oil Stadium.